This study explores the effects of Boletus edulis (porcini mushroom) extract on gut microbiota imbalances caused by antibiotic use. The frequent use of antibiotics often disrupts the natural balance of gut bacteria, leading to reduced microbial diversity and potential health issues. The researchers aimed to determine if porcini extract could help restore this balance by acting as a modulator for gut microbiota.
Through laboratory analysis, the study evaluated the extract’s impact on gut bacteria, immune response, and the levels of essential compounds like short-chain fatty acids (SCFAs). SCFAs are critical for gut health and are often reduced following antibiotic use. The extract was found to enhance the production of SCFAs and other beneficial bacteria while reducing levels of harmful bacteria. Additionally, the mushroom extract demonstrated antioxidant properties, thanks to its rich polyphenolic content, helping to counteract oxidative stress in the gut.
Further analysis showed that the extract selectively inhibited pro-inflammatory markers while promoting anti-inflammatory responses, suggesting potential benefits in reducing inflammation and protecting against conditions worsened by gut inflammation. By influencing specific cytokines – immune system proteins involved in inflammation – the extract may also support immune health. Overall, Boletus edulis extract showed promise as a natural supplement to counteract antibiotic-induced dysbiosis. This research highlights the potential of porcini extract as a functional food ingredient that supports gut health, immune balance, and overall well-being by restoring gut microbiota after antibiotic treatment.
Find more here https://www.mdpi.com/2075-1729/13/7/1481